Cardiovascular effects of
anti-hyperglycemic
therapy
Edoardo Mannucci
Diabetes Agency
Careggi teaching hospital,
Firenze, Italy
ADVANCE
MACE
CV mort.
Effects of intensified glycemic control on CV mortality
Adrenercic activation could
have a negative impact on the
prognosis of
MYOCARDIAL ISCHEMIA
MACE
Secondary prevention of macrovascular events in patients
with type 2 diabetes:
The PROACTIVE Study
Dormandy JA et al., Lancet 2005; 366: 1279
Relative risk SU vs other therapies
vs.
Conventional
0.96
vs.
Insulin
1.03
vs.
Metformin
1.53
MI
0.83
0.91
1.24
Stroke
1.19
1.40
2.12
Mortality
Effect of SU on MACE
Monami M, Ganovese S, Mannucci E – 2013 [in press]
Effect of SU on mortality
Monami M, Ganovese S, Mannucci E – 2013 [in press]