Legenda della tabella: 95%CI=Intevalli di confidenza al 95° percentile, CABG=Bypass aorto-coronarico, HR=Hazard Ratio
Endpoint
Composito
vascolare,
Stroke
PLATO
Ticagrelor
Clopidogrel
di
morte 864/9333 (9.8%) 1014/9291
Reinfarto
e
(11.7%)
HR (95% CI)
0.84 (0.77-0.92)
PLATO-PCI
P
Ticagrelor
<0.001
569/6732 (9.0%)
Clopidogrel
668/6676 (10.7%)
HR (95% CI)
0.84 (0.75-0.94)
P
0.0025
Morte vascolare
353/9333 (4.0%)
442/9291 (5.1%)
0.79 (0.69-0.91)
<0.001
221/6732 (3.4%)
269/6676 (4.3%)
0.82 (0.68-0.98)
0.0250
Morte totale
399/9333 (4.5%)
506/9291 (5.9%)
0.78 (0.69-0.89)
<0.001
252/6732 (3.9%)
311/6676 (5.0%)
0.81 (0.68-0.95)
0.0103
Reinfarto
504/9333 (5.8%)
593/9291 (6.9%)
0.84 (0.75-0.95)
0.005
328/6732 (5.3%)
406/6676 (6.6%)
0.80 (0.69-0.92)
0.0023
Stroke
125/9333 (1.5%)
106/9291 (1.3%)
1.17 (0.91-1.52)
0.22
75/6732 (1.2%)
69/6676
(1.1%)
1.08 (0.78-1.50)
0.6460
Ischemico
96/9333 (1.1%)
91/9291 (1.1%)
0.74
59/6732 (0.9%)
59/6676
(0.9%)
1.0000
Emorragico
23/9333 (0.2%)
13/9291 (0.1%)
0.10
12/6732 (0.2%)
9/6676
(0.1%)
0.6634
Causa sconosciuta
10/9333 (0.1%)
2/9291 (0.02%)
0.04
5/6732 (0.07%)
1/6676
(0.01%)
0.2187
Definita
62/4949
(1.3%)
97/4928
(2.0%)
0.64 (0.46-0.88)
0.0054
Probabile o definita
104/4949 (2.2%)
142/4928
(3.0%)
0.73 (0.57-0.94)
0.0142
132/4949
(2.8%)
179/4928
(3.8%)
0.73 (0.59-0.92)
0.0068
Trombosi di stent
Possibile,
definita
probabile
o
Sanguinamenti maggiori
961/9235 (11.6%) 929/9186 (11.2%) 1.04 (0.95-1.13)
0.43
689/6651 (11.5%) 691/6585
(11.6%)
0.99 (0.89-1.10)
0.8803
CABG-associati
619/9235 (7.4%)
654/9286 (7.9%)
0.95 (0.85-1.06)
0.32
430/6651 (7.1%)
480/6585
(8.0%)
0.89 (0.78-1.01)
0.0745
Non CABG-associati
362/9235
(4.5%)
306/9186 (3.8%)
1.19 (1.02-1.38)
0.03
272/6651 (4.7%)
235/6585
(4.0%)
1.16 (0.97-1.38)
0.1040
Necessità di trasfusione
818/9235 (8.9%)
809/9186 (8.9%)
1.00 (0.91-1.11)
0.96
531/6651 (8.9%)
525/6585
(8.7%)
1.01 (0.89-1.14)
0.9095
Emorragie intracraniche
26/9235 (0.3%)
14/9186 (0.2%)
1.87 (0.98-3.58
0.06
15/6651 (0.3%)
11/6585
(0.2%)
1.36 (0.63-2.97)
0.4364
Fatali
11/9235 (0.1%)
1/9186 (0.01%)
0.02
Non-fatali
15/9235 (0.2%)
13/9186 (0.2%)
0.69