Use Of 70 MeV Proton Beam For Medical Applications At
INFN-LNS:
CATANA
Project
CATANA CATANA CATANA CATANA
CATANA
CATANA
CATANA CATANA CATANA CATANA
M.G. Sabinia,f , G.A.P. Cirronea,f , L. Barone Tonghia, A. Bartolottae, M. Braie, G.Cuttonea , S. Lo Nigrod,f, F.
Maranob, G.A. Nicolettib , G. Priviterac, L. Raffaelea,c, A. Reibaldib, A. Rovellia,V. Salamonec, G. Terie
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
a) INFN-Laboratori Nazionali del Sud, Catania
b) Institute of Ophtalmology -University of Catania
c) Institute of Radiology - University of Catania
d) Physics Department - University of Catania
e) Istituto di Biocomunicazioni - University of Palermo
f) Centro Siciliano di Fisica Nucleare e Struttura della Materia, Catania
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
Centro di AdroTerapia e Applicazioni Nucleari Avanzate
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
• Project for the development of a protontherapy facility
• Collaboration between INFN-Laboratori Nazionali del Sud (Catania), University of Catania and CSFNSM of Catania
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
• Based on the use of the already working INFN-LNS Superconducting Cyclotron
SICILY AND PARTICULARLY CATANIA IS IN A CENTRAL GEOGRAPHICAL POSITION IN THE MEDITERRANEAN AREA AND THEN CATANA SHOULD COLLECT
PATIENTS COMING FROM MEDITERRANEAN EUROPEAN AND EXTRA-EUROPEAN COUNTRIES
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
CATANA
Treatment Procedure
Characteristics of proton beams
Medical Applications
Patient positioning on the computer controlled chair (6 independent
movements)
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
Choroidal Melanoma
Patient immobilization by face mask and bite block
85 - 90 % successfully treating with proton beams
Metallic clips surgically inserted in the eyes for positioning control and
beam alignment by two orthogonal X-Rays tubes
About 300 new cases for year in Italy
Eye control movement during irradiation by means of video camera
Control of the beam features and total dose
Proton irradiation
Total irradiation time: 30 - 60 sec
Dose fraction: 12 - 15 Gy
Fractions number: 4, every 24 h
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
In the world 5000 patients have been already treated with proton
beams
Age related subfoveal macular degenerations with subretinal
neovascular membrane
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
This is the main cause of third age blindness in EC countries
It is a “social disease” for EC
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
EYEPLANCATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
CATANA CATANA
ProtonTherapy Room
A treatment plan is made by the clinical
physicist using the 3D treatment
planning package “EYEPLAN”. The
result of the plan will specify:
• The design of the range modulator
According to the results of the
simulation, the range modulator and
individual patient collimator are
realized. Each treatment plan is
calibrated individually by the clinical
physicist using ionization chamber
placed at the center of the treatment
volume.
• The range shifter position
The isodose curves are also calculated
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
• The fixation light position
• The design of the collimator
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
• The set of predicted clip pictures for
treatment
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANAMainCATANA
CATANA
ionization chambers utilized in the
dosimetry of CATANA project
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
STATUS AND FUTURE PLANS
Experimental Set-up
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
Dosimetry Intercomparison at
Clatterbridge Center for Oncology
 Measurements in air in unmodulated
proton beam
 Measurements in a modulated proton
beam at 4 mm in PMMA
CCO Modulated and Unmodulated Depth Dose (60 MeV)
 Chair and
 The
related devices will be installed in march 2000
treatment line in air has been designed and will be ready in November ‘99
 The
absolute and relative dosimetry has been studied and main choices have
been done (ionization chambers, diodes, radiographic films, TLD and Alanina).
In Feb-Mar ‘ 00 the dosimetric characterization of the CS proton beam will be
carried out.
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
100
The results of the intercomparison (DW )
u.a. (%)
80
LNS PTW Markus/CCO FAR WEST IC-18
LNS EXRADIN T1/CCO FAR WEST IC-18
Modulated Depth Dose
Unmodulated Depth Dose
60
+0.9%
-1.2%
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
Dose Percentage differences in unmodulated proton beam
40
LNS PTW Markus/CCO FAR WEST IC-18
LNS EXRADIN T1/CCO FAR WEST IC-18
20
+0.2%
-1.4%
 The
treatment planning software (EYEPLAN) is already installed at LNS
 The
authorization procedure has been already started
0
0
5
10
15
20
Depth in PMMA (mm)
25
30
Dose Percentage differences in a modulated proton beam
WE EXPECT THE FIRST PATIENT TREATMENT IN
SPRING 2000
CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA CATANA
INFN - LNS