National Animal Facilities Network
Alliance Against Cancer (ACC)
Giudice A., Palma G., Barbieri A., Spinelli M., Carotenuto O., Luciano A., Fontanella M., Arra C.
Unità Operativa di “Sperimentazione Animale” - Istituto Nazionale Tumori Fondazione “ G. Pascale ”
Core Values
Mission
Network Animal Facility aimed to consolidate and to increase the
knowledge between the animal facilities involved cancer research and
trasforming the same in companies.
Excellence
Vision
Services –
Advanced of the quality of the research finalized to the condivision of
protocols, the creation of animal models, the formation of the personal
involved in the research, the creation of web sites.
- Continuous improvement in all aspects
Intellectual Freedom – To transfer knowledge freely according
to ethical principles
To merge the knowledge spin-offs together
Stewardship of Resources – To have the efficient and
effective use of resources, accepting the responsibility our actions
Network Animal Facility will be also:
9 Develop and discovery of new anticancer drugs ;
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New technolgical applications from animal models;
Requirements for accreditation on GMP and quality control;
Develop of intellectual property and patents;
Create new animal models to study tumour biology and its development;
Traslational research units;
Animal Facilities Network
Animal Facilities National Network
Website
CRO - Aviano
Ist.Clinico Humanitas
Rozzano - Milan
Ist.Nazionale Tumori
Naples
ISS & Ist.Regina Elena
Rome
Ist.Scientifico
San Raffaele
Milan
Ist.Nazionale Tumori
Genoa
Ist.Ortopedici Rizzoli
Bologna
Animal House & Laboratories
Objectives
9 Enhanced performances and the molecular
characterization
9 Animal biobanking database of chimeric tumors
9 Increase preclinical performances
9 Collaborations with Pharmaceutical Company for new
anticancer drugs
9 Introduce a biological safety level 3 (BSL- 3)
9 Carcinogenesis applications in mutant mice
Research & Development ( R&D )
Therapeutic and Innovative Diagnostic Approches
Xenograft Models
Hortotopic & Heterotopic
cancer mice models by cellular lines
Colorectal Carcinogenesis Models
Mutant mice
( Cripto KO, CBX and CL-2 transgenic mice)
Outbred & Inbred strains
(CD1) ( Balb/c, C57BL/6J)
9 Melanoma: M14, B16, A375
9 Breast: MCF7, MDA 23
9 Prostate: PC3, LnCaP
9 Fibrosarcoma: HT1080
9 Osteosarcoma: SAOS
9 Epidermoid carcinoma: A431
( Cecal Hernia)
Multiple lesions in Colorectal Cancer
(Cecal Hernia)
In vivo micro-PET imaging