Ian Graham et al. European Heart Journal 2007;28:2375-414 Classes of recommendations Ian Graham et al. European Heart Journal 2007;28:2375-414 Levels of evidence Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 All deaths from circulatory disease in Europe All ages - Year 2000 or circa Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 The relationship of total cholesterol (TC):HDL cholesterol ratio to 10-year fatal CVD events in men and women aged 60 years with and without risk factors, based on a risk function derived from the SCORE project Ian Graham et al. European Heart Journal 2007;28:2375-414 Impact of combinations of risk factors on risk Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Advantages in using the SCORE risk chart • • • • • • • • Intuitive, easy to use tool Takes account of the multifactorial nature of CVD Estimates risk of all atherosclerotic CVD, not just CHD Allows flexibility in management - if an ideal risk factor level cannot be achieved, total risk can still be reduced by reducing other risk factors Allows a more objective assessment of risk over time Establishes a common language of risk for clinicians Shows how risk increases with age The new relative risk chart helps to illustrate how a young person with a low absolute risk may be at a substantially higher and reducible relative risk. Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 Ian Graham et al. European Heart Journal 2007;28:2375-414 SCORE chart: 10-year risk of fatal CVD in populations at high CVD risk based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol Ian Graham et al. European Heart Journal 2007;28:2375-414 SCORE chart: 10-year risk of fatal CVD in populations at low CVD risk based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol Ian Graham et al. European Heart Journal 2007;28:2375-414 SCORE chart: 10-year risk of fatal CVD in populations at high CVD risk based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol: HDL cholesterol ratio Ian Graham et al. European Heart Journal 2007;28:2375-414 SCORE chart: 10-year risk of fatal CVD in populations at low CVD risk based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol: HDL cholesterol ratio Ian Graham et al. European Heart Journal 2007;28:2375-414 Relative risk chart Ian Graham et al. European Heart Journal 2007;28:2375-414